Abstract | PURPOSE: The aim of this study was to compare the hormone receptors' (HR) and HER2/neu status between core needle biopsy (CNB) and residual tumor after surgery of breast cancer treated with neoadjuvant chemotherapy (NAC), and also to evaluate the impact of discordance and other clinicopathological factors on survival. METHODS: Oestrogen receptor (ER), progesterone receptor (PR) and HER2/neu status were evaluated by immunohistochemistry (IHC) on 90 CNBs of primary tumors and surgical specimens after NAC (study group); 53 patients without NAC served as control group, and discordance was compared between the two groups. The association between discordance of HR status after NAC and various other clinicopathological factors was tested with Spearman's test. RESULTS: Pathological complete response (PCR) was achieved in 10 (11.1%) patients after NAC. ER and PR changed significantly more in the study than in the control group. ER and PR discordance was detected in 10 (12.5%) and 17 (21.2%) patients in the NAC group and in 1 (1.8%) and 2 (3.7%) patients in the control group (p=0.04 and p=0.005, respectively). ER discordance was related with HER2/neu change. Furthermore, PR discordance correlated with CNB, ER and treatment response, while HER2/ neu discordance was associated with treatment response (p=0.05). ER discordance was found to be an independent prognostic factor for progression-free survival (PFS) (p=0.02). CONCLUSION:
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Authors | Bala Basak Oven Ustaalioglu, Fugen Aker Vardar, Ahmet Bilici, Gunay Gurleyik, Burcak Erkol, Umut Kefeli, Mehmet Aliustaoglu |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2014 Oct-Dec
Vol. 19
Issue 4
Pg. 879-86
ISSN: 1107-0625 [Print] Cyprus |
PMID | 25536590
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Estrogen
- Receptors, Progesterone
- Receptor, ErbB-2
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Topics |
- Breast Neoplasms
(drug therapy)
- Case-Control Studies
- Disease-Free Survival
- Humans
- Neoadjuvant Therapy
- Receptor, ErbB-2
- Receptors, Estrogen
- Receptors, Progesterone
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