Comparison of T stage, N stage, multifocality, and bilaterality in papillary thyroid carcinoma patients according to the presence of coexisting lymphocytic thyroiditis.

Abstract

PURPOSE:

This study aimed to assess the relationship between coexisting lymphocytic thyroiditis and T-N stages of papillary thyroid carcinoma (PTC) by histopathological analysis.

MATERIALS AND METHODS:

The study included 653 patients who underwent thyroid surgery for PTC at our hospital. Each case was classified as either Hashimoto's thyroiditis (HT), non-Hashimoto type of lymphocytic thyroiditis (NHLT), or normal according to the histopathology of thyroid parenchyma. Patient age, gender, surgical modality, location, T stage, N stage, multifocality and bilaterality were compared according to the histopathology.

RESULTS:

The prevalence of coexisting lymphocytic thyroiditis was 25.8% (169/653); HT (7.5%, 49/653) and NHLT (18.3%, 120/653). There were no significant differences in T stage, N stage, multifocality and bilaterality with regard to coexisting lymphocytic thyroiditis, regardless of whether HT and NHLT were considered collectively or discretely. Primary tumor size (p < 0.0001), location (p = 0.0011), N stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to T stage, and gender (p = 0.0193), primary tumor size (p < 0.0001), T stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to N stage.

CONCLUSIONS:

PTC patients with coexisting lymphocytic thyroiditis did not differ from those with normal parenchyma in terms of T stage, N stage, multifocality and bilaterality.

• Authors: Jin Young Park, Dong Wook Kim, Ha Kyung Park, Tae Kwun Ha, Soo Jin Jung, Do Hun Kim, Sang Kyun Bae
• Journal: Endocrine research (Endocr Res) Vol. 40 Issue 3 Pg. 151-5 ( 2015) ISSN: 1532-4206 [Electronic] England
• PMID: 25531396 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Carcinoma, Papillary (complications, pathology, surgery)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Thyroid Gland (pathology, surgery)
• Thyroid Neoplasms (complications, pathology, surgery)
• Thyroiditis, Autoimmune (complications, pathology, surgery)
• Young Adult