The role of ¹²³I imaging in the evaluation of infants with mild congenital hypothyroidism.

Abstract

BACKGROUND/AIMS:

Controversy exists regarding the diagnosis and treatment of mild congenital hypothyroidism (MCH). We studied the value of (123)I imaging in patients with MCH.

METHODS:

Retrospective chart review of infants and children <4 years of age who underwent (123)I imaging: group 1 = MCH [thyroid-stimulating hormone (TSH) <25 µIU/ml, normal free T4/T3], group 2 = severe congenital hypothyroidism (TSH ≥25 µIU/ml), and group 3 = MCH in infancy imaged after treatment withdrawal at age 3 years. Data collected included 4- and 24-hour (123)I uptake, TSH, free T4/total T3 at imaging, age at imaging, and levothyroxine (L-T4) dose at 1 year of.

RESULTS:

Thirty-six patients underwent (123)I imaging. In group 1 (n = 20, median TSH: 8.49 µIU/ml), 85% had abnormal imaging consistent with dyshormonogenesis. Two patients were referred after 1 year of age. The median age at imaging for the remaining 18 patients was 54 days. Median L-T4 dose at 1 year of age for these 18 patients was 2.8 μg/kg, which is consistent with dyshormonogenesis. Ninety-one percent of group 2 (n = 11, median TSH: 428.03 µIU/ml) had abnormal imaging. The median age at imaging was 13 days. Four patients in group 3 had abnormal (123)I imaging and restarted treatment.

CONCLUSION:

(123)I imaging is a valuable tool for evaluation, diagnosis, and treatment of MCH.

• Authors: Evan Graber, Molly O Regelmann, Rachel Annunziato, Josef Machac, Robert Rapaport
• Journal: Hormone research in paediatrics (Horm Res Paediatr) Vol. 83 Issue 2 Pg. 94-101 ( 2015) ISSN: 1663-2826 [Electronic] Switzerland
• PMID: 25531155 (Publication Type: Journal Article)
• Copyright: © 2014 S. Karger AG, Basel.

Chemical References

• Iodine Isotopes
• Thyroid Hormones

Topics

• Congenital Hypothyroidism (blood, diagnostic imaging)
• Female
• Humans
• Infant
• Infant, Newborn
• Iodine Isotopes (administration & dosage)
• Male
• Radionuclide Imaging
• Retrospective Studies
• Thyroid Dysgenesis (blood, diagnostic imaging)
• Thyroid Hormones (blood)