Relative risk of lung obstruction in relation to PM10 concentration as assessed by pulmonary function tests.

Abstract

Epidemiological studies show that long-term exposure to air pollution may increase the relative risk of obstructive lung diseases such as COPD or asthma. The risk of increased obstruction is higher among residents living in close proximity to high traffic routes where there are high concentrations of PM(10). The present study consists of two parts: the measurement of the concentration of air pollutants and of pulmonary function in selected groups of people. The study was conducted in Warsaw, Poland, in seven localizations with typical urban canyon characteristics and roads with high traffic. The control group consisted of people living in other regions of Poland with a significantly lower (p < 0.05) concentration of air pollutants. The study was performed in the years 2008-2012. The incidence of obstructive lung disease was determined according to the GOLD guidelines. The study subjects were all non-smokers. The relative risk of disease took into account different exposure times to air pollutants. The findings indicate that an increase in PM(10) concentration by each 10 μg/m(3) caused an increase in the relative risk of lung obstruction by a factor of 1.27, 1.24, and 1.19 for the residence period in the vicinity to heavy traffic city roads for 20, 30, and 40 years, respectively as compared with the residence of rural unpolluted areas. A decrease in the number of people with lung obstruction with the length of residence actually indicates that people exposed to high concentrations of PM(10) become affected by lung obstruction at a lower age. The study shows a positive relative risk of lung obstruction due to an exposure to high PM(10) emission.

• Authors: Łukasz Adamkiewicz, Anna Gayer, Dominika Mucha, Artur J Badyda, Piotr Dąbrowiecki, Piotr Grabski
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 849 Pg. 83-91 ( 2015) ISSN: 0065-2598 [Print] United States
• PMID: 25523626 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Air Pollutants
• Particulate Matter
• Carbon Monoxide
• Nitrous Oxide

Topics

• Aged
• Air Pollutants (adverse effects)
• Airway Obstruction (etiology)
• Carbon Monoxide (adverse effects)
• Environmental Monitoring
• Humans
• Middle Aged
• Nitrous Oxide (adverse effects)
• Particle Size
• Particulate Matter (adverse effects)
• Poland
• Respiratory Function Tests (methods)
• Risk Assessment