Abstract | BACKGROUND: MATERIALS AND METHODS:
HBsAg-positive individuals attending this clinic were tested for anti- HDAg antibodies (anti-HDAbs). All samples positive for anti-HDAb were also tested for detection of HDV RNA by reverse transcription-polymerase chain reaction (RT-PCR). A questionnaire consisting of demographic characteristics and potential risk factors for acquisition of HDV was filled for each individual. RESULTS: Among 1038 individuals, HBsAg was detected in 660 (63.6%) cases following blood donation and in 378 (36.4%) cases following blood testing. In this study, 23 [2.2%, 95% confidence interval (CI) = 1.3-3.2%] patients were HDV-seropositive. In HDV-seropositive patients, 14 (60.9%, 95% CI = 39.1-78.3%) were positive for HDV RNA. HDV-seropositive cases were more likely to have evidence of severe forms of hepatitis than the group of individuals without anti-HDAb (P < 0.01). Familial history of hepatitis D infection was more observed in HDV-seropositive patients than in individuals negative for anti-HDAb (P < 0.01). CONCLUSION: The seroprevalence of HDV in HBsAg-positive individuals in this study was about 2% which seems to be lower than the global prevalence of HDV.
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Authors | M Keshvari, S M Alavian, B Aghaee, B Behnava, M Mahdavi, M Gholami Fesharaki, H Sharafi |
Journal | Transfusion medicine (Oxford, England)
(Transfus Med)
Vol. 24
Issue 6
Pg. 411-7
(Dec 2014)
ISSN: 1365-3148 [Electronic] England |
PMID | 25523297
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2014 British Blood Transfusion Society. |
Chemical References |
- Hepatitis B Surface Antigens
- RNA, Viral
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Topics |
- Adult
- Aged
- Blood Donors
- Coinfection
(blood, epidemiology)
- Female
- Hepatitis B
(blood, epidemiology)
- Hepatitis B Surface Antigens
(blood)
- Hepatitis D
(blood, epidemiology)
- Hepatitis Delta Virus
- Hospitals, Special
- Humans
- Iran
- Male
- Middle Aged
- RNA, Viral
(blood)
- Seroepidemiologic Studies
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