Abstract | BACKGROUND: METHODS: [ 18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and standardized clinical assessments using the Coma Recovery Scale-Revised were performed after administration of 10 mg zolpidem or placebo in a randomized double blind 2-day protocol. PET data preprocessing and comparison with a healthy age-matched control group were performed using statistical parametric mapping (SPM8). RESULTS: Behaviorally, all patients recovered functional communication after administration of zolpidem (i.e., emergence from the MCS). FDG-PET showed increased metabolism in dorsolateral prefrontal and mesiofrontal cortices after zolpidem but not after placebo administration. CONCLUSION: Our data show a metabolic activation of prefrontal areas, corroborating the proposed mesocircuit hypothesis to explain the paradoxical effect of zolpidem observed in some patients with DOC. It also suggests the key role of the prefrontal cortices in the recovery of functional communication and object use in hypoxic patients with chronic MCS.
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Authors | Camille Chatelle, Aurore Thibaut, Olivia Gosseries, Marie-Aurélie Bruno, Athena Demertzi, Claire Bernard, Roland Hustinx, Luaba Tshibanda, Mohamed A Bahri, Steven Laureys |
Journal | Frontiers in human neuroscience
(Front Hum Neurosci)
Vol. 8
Pg. 917
( 2014)
ISSN: 1662-5161 [Print] Switzerland |
PMID | 25520636
(Publication Type: Journal Article)
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