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Acanthamoeba polyphaga mimivirus prevents amoebal encystment-mediating serine proteinase expression and circumvents cell encystment.

Abstract
Acanthamoeba is a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus, Acanthamoeba polyphaga mimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.
AuthorsPaulo Boratto, Jonas Dutra Albarnaz, Gabriel Magno de Freitas Almeida, Lucas Botelho, Alide Caroline Lima Fontes, Adriana Oliveira Costa, Daniel de Assis Santos, Cláudio Antônio Bonjardim, Bernard La Scola, Erna Geessien Kroon, Jônatas Santos Abrahão
JournalJournal of virology (J Virol) Vol. 89 Issue 5 Pg. 2962-5 (Mar 2015) ISSN: 1098-5514 [Electronic] United States
PMID25520511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015, American Society for Microbiology. All Rights Reserved.
Chemical References
  • Serine Proteases
Topics
  • Acanthamoeba (enzymology, growth & development, virology)
  • Host-Parasite Interactions
  • Mimiviridae (growth & development)
  • Serine Proteases (biosynthesis)
  • Spores, Protozoan (growth & development)

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