[Pathogenesis of autoantibodies in demyelinating disorders of the central nervous system].

Abstract

Several autoantibodies in relation to central nervous system demyelinating diseases (CDD) have been reported. Among them, anti-aquaporin 4(AQP4) antibody in neuromyelitis optica (NMO) is a reliable marker for the diagnosis of NMO and the antibody is thought to be closely related to its pathogenesis. Another antibody, anti-myelin oligodendrocyte glycoprotein (MOG) antibody is recently recognized in relevance to CDD, especially in seronegative NMO. Anti-MOG antibodies are also paid attention in pediatric acute disseminated encephalomyelitis (ADEM) and optic neuritis, however the roles for the pathogenesis in these disorders are still not clear. Generally, B cells and autoantibodies are thought to have certain roles in CDD.

• Authors: Keiko Tanaka, Masami Tanaka
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 72 Issue 11 Pg. 2067-72 (Nov 2014) ISSN: 0047-1852 [Print] Japan
• PMID: 25518394 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aquaporin 4
• Autoantibodies

Topics

• Aquaporin 4 (immunology)
• Autoantibodies (immunology)
• B-Lymphocytes (immunology)
• Central Nervous System (immunology)
• Humans
• Neuromyelitis Optica (immunology)