Abstract | OBJECTIVES: METHODS: Forty female Wistar albino rats weighing 250-300 g were randomized into five experimental groups (each with n = 8) as follows:1) a sham group subjected to a sham surgical procedure and administered only tap water; 2) a control group subjected to a standardized surgical procedure to induce ischemic colitis and administered only tap water; 3) and 4) treatment groups subjected to surgical induction of ischemic colitis followed by the postoperative administration of 5 mg/kg or 10 mg/kg vardenafil, respectively; and 5) a treatment group subjected to surgical induction of ischemic colitis followed by postoperative administration of pentoxifylline at 50 mg/kg/day per day as a single dose for a 3-day period. All animals were sacrificed at 72 h post-surgery and subjected to relaparotomy. We scored the macroscopically visible damage, measured the ischemic area and scored histopathology to determine the severity of ischemia. Tissue malondialdehyde levels were also quantified. RESULTS: CONCLUSION: Our findings indicate that vardenafil and pentoxifylline are effective treatment options in an animal model of ischemic colitis. The positive clinical effects produced by these drugs are likely due to their influence on the hemodynamics associated with vascular smooth muscle and platelet functions.
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Authors | Mehmet Aziret, Oktay Irkorucu, Enver Reyhan, Hasan Erdem, Koray Das, Selvinaz Ozkara, Ali Surmelioglu, Selim Sozen, Ilhan Bali, Sulleyman Cetinkunar, Kamuran Cumhur Deger |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 69
Issue 11
Pg. 763-9
(Nov 2014)
ISSN: 1980-5322 [Electronic] United States |
PMID | 25518035
(Publication Type: Journal Article)
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Chemical References |
- Imidazoles
- Phosphodiesterase 5 Inhibitors
- Piperazines
- Sulfones
- Triazines
- Malondialdehyde
- Vardenafil Dihydrochloride
- Pentoxifylline
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Topics |
- Animals
- Colitis, Ischemic
(drug therapy, pathology, surgery)
- Colon
(pathology, surgery)
- Disease Models, Animal
- Female
- Hemodynamics
(drug effects)
- Imidazoles
(administration & dosage)
- Malondialdehyde
(analysis)
- Pentoxifylline
(administration & dosage)
- Phosphodiesterase 5 Inhibitors
(administration & dosage)
- Piperazines
(administration & dosage)
- Random Allocation
- Rats, Wistar
- Reproducibility of Results
- Sulfones
(administration & dosage)
- Time Factors
- Treatment Outcome
- Triazines
(administration & dosage)
- Vardenafil Dihydrochloride
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