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A case of intracranial solitary fibrous tumor/hemangiopericytoma with dedifferentiated component.

Abstract
We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.
AuthorsAkira Maekawa, Kenichi Kohashi, Yuichi Yamada, Akira Nakamizo, Koji Yoshimoto, Masahiro Mizoguchi, Toru Iwaki, Yoshinao Oda
JournalNeuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology) Vol. 35 Issue 3 Pg. 260-5 (Jun 2015) ISSN: 1440-1789 [Electronic] Australia
PMID25516114 (Publication Type: Case Reports, Journal Article)
Copyright© 2014 Japanese Society of Neuropathology.
Chemical References
  • NAB2 protein, human
  • Repressor Proteins
  • STAT6 Transcription Factor
  • STAT6 protein, human
Topics
  • Brain Neoplasms (genetics, pathology)
  • Genes, p53
  • Hemangiopericytoma (genetics, pathology)
  • Humans
  • Male
  • Middle Aged
  • Repressor Proteins (metabolism)
  • STAT6 Transcription Factor (genetics)
  • Solitary Fibrous Tumors (genetics, pathology)

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