Abstract |
We report the case of a 51-year-old Japanese man with an intracranial dedifferentiated solitary fibrous tumor/ hemangiopericytoma (SFT/HPC) identified morphologically and immunohistochemically, comprised of a typical SFT/HPC with a high-grade pleomorphic component. NAB2-STAT6 fusion transcripts were detected by reverse transcriptase polymerase chain reaction in both the conventional and high-grade components. The tumor cells in both components showed the nuclear expression of STAT6 protein, indicating the diagnostic value of these examinations. Intracranial dedifferentiated SFT/HPC is a very rare but important differential diagnosis in intracranial pleomorphic tumors.
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Authors | Akira Maekawa, Kenichi Kohashi, Yuichi Yamada, Akira Nakamizo, Koji Yoshimoto, Masahiro Mizoguchi, Toru Iwaki, Yoshinao Oda |
Journal | Neuropathology : official journal of the Japanese Society of Neuropathology
(Neuropathology)
Vol. 35
Issue 3
Pg. 260-5
(Jun 2015)
ISSN: 1440-1789 [Electronic] Australia |
PMID | 25516114
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2014 Japanese Society of Neuropathology. |
Chemical References |
- NAB2 protein, human
- Repressor Proteins
- STAT6 Transcription Factor
- STAT6 protein, human
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Topics |
- Brain Neoplasms
(genetics, pathology)
- Genes, p53
- Hemangiopericytoma
(genetics, pathology)
- Humans
- Male
- Middle Aged
- Repressor Proteins
(metabolism)
- STAT6 Transcription Factor
(genetics)
- Solitary Fibrous Tumors
(genetics, pathology)
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