[Combination chemotherapy with bronchial arterial infusion (BAI) and systemic chemotherapy in advanced non-small cell lung cancer].

Abstract

Five patients of advanced non-small cell lung cancer with atelectasis and/or poor performance status were treated with combination MVP therapy consisting of bronchial arterial infusion (BAI) using cisplatin (50 mg) and simultaneous systemic MVP therapy. The tumor size reduced more than 50% in three patients, and less than 25% in one patient. In another patient the tumor size was not measurable. Four of five patients showed disappearance of atelectasis, and three of four patients showed improvement of performance status. Average time taken was 13 and 17 days, respectively. We expect that combination MVP therapy has beneficial effects not only for relieving local symptoms and improving performance status within shorter period, but also achieving a better prognosis.

• Authors: I Houya, I Kimura, M Nagata, K Kuramitsu, H Kiuchi, Y Sakamoto, K Yamamoto, Y Dohi, K Kaneko
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 16 Issue 8 Pt 2 Pg. 2697-700 (Aug 1989) ISSN: 0385-0684 [Print] Japan
• PMID: 2551216 (Publication Type: English Abstract, Journal Article)

Chemical References

• Mitomycins
• Mitomycin
• Cisplatin
• Vindesine

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Bronchial Arteries
• Carcinoma, Non-Small-Cell Lung (drug therapy)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Drug Evaluation
• Female
• Humans
• Infusions, Intra-Arterial
• Infusions, Intravenous
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Mitomycin
• Mitomycins (administration & dosage)
• Remission Induction
• Vindesine (administration & dosage)