[Diagnosis of hereditary angioedema].

Abstract

Hereditary angioedema is a rare disease, potentially life-threatening. It requires a specific treatment. Angioedema without wheals associated with abdominal attacks are very specific of this disease. Antigenemy and functional C1Inhibitor assays are necessary for the diagnosis. The hereditary angioedema with normal C1Inh (type III) is a diagnostic challenge. Bradykinin, secondary to kallikrein-kinin system activation is the key mediator of hereditary angioedema. Female are more symptomatic. Attacks can be induced by menstruations, pregnancies or contraceptive pills.

• Authors: Laurence Bouillet
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 44 Issue 1 Pg. 52-6 (Jan 2015) ISSN: 2213-0276 [Electronic] France
• Vernacular Title: Diagnostic des angioedèmes héréditaires.
• PMID: 25511656 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Chemical References

• Complement C1 Inhibitor Protein
• Kinins
• Kallikreins
• Bradykinin

Topics

• Angioedemas, Hereditary (diagnosis, etiology)
• Bradykinin (adverse effects, physiology)
• Complement C1 Inhibitor Protein (genetics)
• Female
• Humans
• Kallikreins (metabolism)
• Kinins (metabolism)
• Pregnancy