Abstract | BACKGROUND: OBJECTIVE: Compare the effective treatment of calcitriol regimens (loaded and titrated) in control hypocalcemic hyperparathyroid (HPT) patients who were referred for parathyroidectomy. MATERIAL AND METHOD: A randomized control, open labeled study of 25 patients who underwent parathyroidectomy in Rajavithi Hospital from August 2009 to September 2010 was conducted. The authors randomized 25 patients with chronic kidney disease in two treatment arms of calcitriol (A: Titrated dose regimen, B: Loaded dose regimen), that met criteria. Biochemical factors available within 2 weeks before and after surgery were recorded and analyzed. RESULT: No significant difference was observed in amount of calcium gluconate intravenous use, hypocalcemia and hospital admission durations between titrated and loaded regimen groups, i.e., p = 0.160, 0.645 and 0.460, respectively. Loaded regimen ameliorated the mean reduction of day 7 postoperative mean change of serum calcium level by 0.33±0.99 mg/dl and median change by 2.88 mg/dl (min, max = -0.80, 5.64) compared with titrate regimen mean change ofserum calcium level by 2.68±2.16 mg/dl; median change 0.28 mg/dl (min, max = -0.84, 1.80) with significance, p = 0.036. CONCLUSION:
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Authors | Sathit Niramitmahapanya, Chadsuphar Sirirachta, Benjawan L Niramitmahapanya, Chaicharn Deerochanawong, Udom Krairitichai, Pornake Athipan |
Journal | Journal of the Medical Association of Thailand = Chotmaihet thangphaet
(J Med Assoc Thai)
Vol. 97 Suppl 11
Pg. S56-61
(Nov 2014)
ISSN: 0125-2208 [Print] Thailand |
PMID | 25509696
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Calcitriol
(administration & dosage)
- Female
- Humans
- Hypocalcemia
(drug therapy)
- Male
- Middle Aged
- Parathyroidectomy
(adverse effects, methods)
- Renal Insufficiency, Chronic
(blood, drug therapy)
- Treatment Outcome
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