[Clinical significance of HLA-DRB1 and HLA-DPB1 gene polymorphisms in cirrhosis patients].

Abstract

OBJECTIVE:

To investigate the genetic association between cirrhosis and polymorphisms in the genes encoding major histocompatibility complex, class II (HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1).

METHODS:

A population of 168 parent/offspring trios, in which the proband had a diagnosis of hepatitis B virus infection with clinical signs of cirrhosis.The HLA-DRB1 and DPB 1 gene polymorphisms of rs24755213 and rs202176660 were detected by PCR and single nucleotide polymorphism (SNP) genotyping.Correlation analysis and haplotype relative risk analysis were carried out.

RESULTS:

A/G genotypes were detected in rs24755213 of HLA-DRB1 and C/T genotypes were detected in rs202176660 of DPB1.The rs24755213 allele was associated with cirrhosis (P=0.014), with the G allele identified as a protective factor (Z=-2.33) and the A allele identified as a hazard factor (Z=2.33).The rs202176660 allele was also associated with cirrhosis (P =0.026), with the T allele identified as a protective factor (Z=-2.06) and the C allele identified as a hazard factor (Z=2.06).The haplotypes of G/T and A/C in rs24755213 and rs202176660 respectively were associated with cirrhosis (P =0.037 and 0.002, Z=-2.12 and 2.09 respectively).

CONCLUSION:

In this group of Chinese patients with hepatitis B virus-related cirrhosis, polymorphisms in the HLA-DRB 1 and DPB1 genes were associated with cimhosis.

• Authors: Weifeng Zhao, Shuyuan Liu, Jingpei Du, Changan Li, Qian Dou, Jia Shang
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 22 Issue 10 Pg. 744-6 (Oct 2014) ISSN: 1007-3418 [Print] China
• PMID: 25496863 (Publication Type: Journal Article)

Chemical References

• HLA-DP beta-Chains
• HLA-DPB1 antigen
• HLA-DRB1 Chains

Topics

• Alleles
• Genotype
• HLA-DP beta-Chains (genetics)
• HLA-DRB1 Chains (genetics)
• Haplotypes
• Humans
• Liver Cirrhosis (genetics)
• Polymorphism, Genetic