Abstract | OBJECTIVES: METHODS: RESULTS: Plasma PAPP-A was strongly elevated upon STEMI, UFH-administration and PCI with mean concentrations (95%-confidence interval) pre-PCI, post-PCI, day 1, and day 2 of 13.0 (11.2;15.2), 14.8 (13.1;16.8), 1.03 (0.90;1.18), and 1.08 (0.92;1.28) μg/L, respectively (p<0.0001). Pre-PCI concentrations of IGFBP-4, CT-IGFBP-4 and NT-IGFBP-4 were 154 (142;166), 53 (47;60) and 136 (122;150) μg/L, and levels were unaltered post-PCI. Concentrations increased on day 1 by 63 (43;87)%, 69 (36;110)%, and 47 (21;79)%, respectively (p<0.0001), i.e. at a time point when PAPP-A levels had normalized. CONCLUSION: Plasma IGFBP-4-fragment levels are not acutely altered in patients with STEMI treated with UFH and PCI. Thus, they possess potentials as prognostic markers in ACS patients.
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Authors | Rikke Hjortebjerg, Søren Lindberg, Søren Hoffmann, Jan S Jensen, Claus Oxvig, Mette Bjerre, Jan Frystyk |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 48
Issue 4-5
Pg. 322-8
(Mar 2015)
ISSN: 1873-2933 [Electronic] United States |
PMID | 25489725
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anticoagulants
- Biomarkers
- Insulin-Like Growth Factor Binding Protein 4
- Heparin
- Pregnancy-Associated Plasma Protein-A
- PAPPA protein, human
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Biomarkers
(blood)
- Female
- Heparin
(therapeutic use)
- Humans
- Insulin-Like Growth Factor Binding Protein 4
(blood)
- Male
- Middle Aged
- Myocardial Infarction
(blood, diagnosis, therapy)
- Percutaneous Coronary Intervention
(trends)
- Pregnancy-Associated Plasma Protein-A
(metabolism)
- Prospective Studies
- Treatment Outcome
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