Abstract | INTRODUCTION: AREAS COVERED: This review describes the eCB system's role in modulating cell signaling within the brain. There is a specific focus on eCB's regulation of monoamine neurotransmission and the stress axis, as well as how dysfunction of this interaction can contribute to the development of psychiatric disorders. Additionally, the review provides discussion on compounds and drugs that target this system and might prove to be successful for the treatment of mood-related psychiatric disorders. EXPERT OPINION: The discovery of increasingly selective modulators of CB receptors should enable the identification of optimal therapeutic strategies. It should also maximize the likelihood of developing safe and effective treatments for debilitating psychiatric disorders.
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Authors | Ryan Wyrofsky, Paul McGonigle, Elisabeth J Van Bockstaele |
Journal | Expert opinion on drug discovery
(Expert Opin Drug Discov)
Vol. 10
Issue 1
Pg. 17-36
(Jan 2015)
ISSN: 1746-045X [Electronic] England |
PMID | 25488672
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Antipsychotic Agents
- Endocannabinoids
- Receptors, Cannabinoid
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Topics |
- Affect
(drug effects)
- Animals
- Antipsychotic Agents
(chemistry, pharmacology, therapeutic use)
- Brain
(drug effects, metabolism)
- Drug Discovery
(methods)
- Endocannabinoids
(metabolism)
- Humans
- Mental Disorders
(drug therapy, metabolism, psychology)
- Molecular Structure
- Receptors, Cannabinoid
(metabolism)
- Signal Transduction
(drug effects)
- Stress, Psychological
(drug therapy, metabolism, psychology)
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