The MTHFR C677T polymorphism contributes to increased risk of Alzheimer's disease: evidence based on 40 case-control studies.
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| Abstract |
The association between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and Alzheimer's Disease (AD) risk has been widely reported with inconsistent results. We performed an updated meta-analysis of all available studies to clarify this situation. We conducted a comprehensive literature search in PubMed Alzgene, Embase, and Chinese Biomedical Literature database (CBM) for the period up to June 2014. Finally, a total of 40 case-control studies with 4503 AD cases and 5767 controls were included. Overall, significant increased AD risk was found, when all studies were pooled into the meta-analysis. In subgroup analyses stratified by ethnicity, age of onset, and APOE ϵ4 status, significant increased AD risk was found in Asians, late-onset AD, and APOE ϵ4 carriers, but not in Caucasians, early-onset AD, and non-APOE ϵ4 carriers. The present meta-analysis suggested that the MTHFR is a candidate gene for AD susceptibility. The MTHFR C677T polymorphism may be a risk factor for AD in Asians, APOE ϵ4 carriers, and late-onset AD. Further, investigations taking the potential gene-gene and gene-environmental interactions into consideration for the MTHFR C677T polymorphism should be conducted.
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| Authors | Qiliu Peng, Xianjun Lao, Xiuli Huang, Xue Qin, Shan Li, Zhiyu Zeng |
| Journal | Neuroscience letters (Neurosci Lett) Vol. 586 Pg. 36-42 (Jan 23 2015) ISSN: 1872-7972 [Electronic] Ireland |
| PMID | 25486592 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
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