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The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors.

AbstractBACKGROUND:
The aims of this study were to investigate the immunolocalization of ezrin and its relationship with the podoplanin expression in keratocystic odontogenic tumors.
MATERIAL AND METHODS:
The immunohistochemical expressions of ezrin and podoplanin by odontogenic epithelium were evaluated in keratocystic odontogenic tumors using monoclonal antibodies.
RESULTS:
Our results showed strong cytoplasmic ezrin and membranous podoplanin expressions in basal epithelial layer of all keratocystic odontogenic tumors. The cytoplasmic and membranous ezrin expressions were also detected in suprabasal epithelial layers of tumors. Statistically significant difference between cellular immunolocalization of ezrin and podoplanin odontogenic epithelium were found by Wilcoxon's test (p < 0.05). No correlation between both proteins in keratocystic odontogenic tumors was detected by Spearman test.
CONCLUSIONS:
These results suggest that ezrin and podoplanin may contribute to the expansive growth and local invasiveness of keratocystic odontogenic tumors. Additionally, as both proteins were overexpressed by odontogenic epithelium, their possible roles need to be further explored in benign odontogenic tumors.
AuthorsDenise Tostes Oliveira, Laís Priscila de Santis, Agnes Assao, Kellen Cristine Tjioe, Suely Nonogaki, José Roberto Pereira Lauris, Fernando Augusto Soares
JournalBMC oral health (BMC Oral Health) Vol. 14 Pg. 150 (Dec 05 2014) ISSN: 1472-6831 [Electronic] England
PMID25480364 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Biomarkers, Tumor
  • Cytoskeletal Proteins
  • Membrane Glycoproteins
  • PDPN protein, human
  • ezrin
Topics
  • Adolescent
  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Biomarkers, Tumor (analysis)
  • Cell Membrane (chemistry)
  • Child
  • Cytoplasm (chemistry)
  • Cytoskeletal Proteins (analysis)
  • Epithelium (chemistry)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Mandibular Neoplasms (chemistry, pathology)
  • Maxillary Neoplasms (chemistry, pathology)
  • Membrane Glycoproteins (analysis)
  • Middle Aged
  • Odontogenic Tumors (chemistry, pathology)
  • Young Adult

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