Arginine deprivation in cancer therapy.

There has been an increased and renewed interest in metabolic therapy for cancer, particularly Arg deprivation. The purpose of this review is to highlight recent studies that focus on Arg-dependent malignancies with Arginine (Arg)-degrading enzymes, including arginase and Arg deiminase.
New developments in this area include understanding of the role of most significantly downregulated gene regulating amino acid metabolism, argininosuccinate synthetase and its expression and therapeutic relevance in different tumors. Recent studies have also shed light on the mechanism of tumor cell death with Arg deprivation, with arginase and pegylated Arg deiminase. Particularly important is understanding the mechanism of resistance that cancers develop after such drug exposure. Finally, recent clinical trials have been performed or are ongoing to use Arg deprivation as treatment for advanced malignancies.
Arg deprivation is a promising approach for the treatment of various malignancies.
AuthorsLynn G Feun, Macus Tien Kuo, Niramol Savaraj
JournalCurrent opinion in clinical nutrition and metabolic care (Curr Opin Clin Nutr Metab Care) Vol. 18 Issue 1 Pg. 78-82 (Jan 2015) ISSN: 1473-6519 [Electronic] England
PMID25474015 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antineoplastic Agents
  • Polyethylene Glycols
  • Arginine
  • Hydrolases
  • Arginase
  • ADI PEG20
  • arginine deiminase
  • Argininosuccinate Synthase
  • Antineoplastic Agents (pharmacology, therapeutic use)
  • Arginase (metabolism, pharmacology, therapeutic use)
  • Arginine (metabolism)
  • Argininosuccinate Synthase (metabolism)
  • Humans
  • Hydrolases (metabolism, pharmacology, therapeutic use)
  • Neoplasms (drug therapy, metabolism)
  • Polyethylene Glycols (metabolism, pharmacology, therapeutic use)

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