An epigenetic therapy for diffuse intrinsic pontine gliomas.

Abstract	Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.
Authors	Vijay Ramaswamy, Marc Remke, Michael D Taylor
Journal	Nature medicine (Nat Med) Vol. 20 Issue 12 Pg. 1378-9 (Dec 2014) ISSN: 1546-170X [Electronic] United States
PMID	25473916 (Publication Type: Journal Article, Comment)
Chemical References	Benzazepines GSK-J4 Histones Pyrimidines Jumonji Domain-Containing Histone Demethylases KDM6B protein, human
Topics	Animals Apoptosis (drug effects) Benzazepines (pharmacology) Brain Stem Neoplasms (genetics) Cell Proliferation (drug effects) Gene Expression Regulation, Neoplastic Glioma (genetics) Histones (drug effects) Humans Jumonji Domain-Containing Histone Demethylases (antagonists & inhibitors) Pyrimidines (pharmacology)

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