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Evidence for the efficacy of aztreonam for inhalation solution in the management of Pseudomonas aeruginosa in patients with cystic fibrosis.

Abstract
Chronic airway infection in cystic fibrosis (CF) is a main cause of the increased morbidity and mortality found with this disease. The most common cause of Gram-negative infection is Pseudomonas aeruginosa. The introduction of inhaled antibiotics has changed the lives of affected patients and the clinical outcome of this infection; this article focuses on the use of inhaled antibiotics in chronic P. aeruginosa infection in CF, and specifically on studies including the use of inhaled aztreonam lysine in P. aeruginosa infection. Studies were identified using PubMed and ClinicalTrials.gov, searching for ‘inhaled aztreonam’ and ‘cystic fibrosis’. Inhaled aztreonam is an important new treatment option for chronic P. aeruginosa infection in CF. Long-term studies have shown that the drug is safe and superior to inhaled tobramycin in these specific infections.
AuthorsChristine Hansen, Marianne Skov
JournalTherapeutic advances in respiratory disease (Ther Adv Respir Dis) Vol. 9 Issue 1 Pg. 16-21 (Feb 2015) ISSN: 1753-4666 [Electronic] England
PMID25471692 (Publication Type: Journal Article, Review)
Chemical References
  • Anti-Bacterial Agents
  • Aztreonam
Topics
  • Administration, Inhalation
  • Anti-Bacterial Agents (administration & dosage, adverse effects)
  • Aztreonam (administration & dosage, adverse effects)
  • Cystic Fibrosis (complications, diagnosis)
  • Humans
  • Pseudomonas Infections (diagnosis, drug therapy, microbiology)
  • Pseudomonas aeruginosa (drug effects, pathogenicity)
  • Recurrence
  • Respiratory Tract Infections (diagnosis, drug therapy, microbiology)
  • Treatment Outcome

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