Gastroprotective potentials of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats.

Abstract

This study investigated the protective effects of the ethanolic extract of Mukia maderaspatana against indomethacin-induced gastric ulcer in rats. Gastric ulceration was induced by single intraperitoneal injection of indomethacin (30 mg/kg b.wt.). M. maderaspatana extract produced significant reduction in gastric mucosal lesions, malondialdehyde and serum tumour necrosis factor-α associated with a significant increase in gastric juice mucin content and gastric mucosal catalase, nitric oxide and prostaglandin E2 levels. The volume and acidity of the gastric juice decreased in pretreated rats. The plant extract was evaluated in the gastric juice of rats, untreated has showed near normal levels in pretreated rats. The M. maderaspatana was able to decrease acidity and increase the mucosal defence in the gastric area, therefore justifying its use as an antiulcerogenic agent. Ranitidine significantly increased pH value and decreased pepsin activity and gastric juice free and total acidity. The anti-ulcer effect was further confirmed histologically.

• Authors: G Gomathy, D Venkatesan, S Palani
• Journal: Natural product research (Nat Prod Res) Vol. 29 Issue 22 Pg. 2107-11 ( 2015) ISSN: 1478-6427 [Electronic] England
• PMID: 25471339 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Mucins
• Plant Extracts
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Malondialdehyde
• Catalase
• Dinoprostone
• Indomethacin

Topics

• Animals
• Anti-Ulcer Agents (isolation & purification, pharmacology)
• Catalase (metabolism)
• Cucurbitaceae (chemistry)
• Dinoprostone (metabolism)
• Gastric Juice (chemistry)
• Gastric Mucosa (drug effects)
• Indomethacin (adverse effects)
• Male
• Malondialdehyde (metabolism)
• Mucins (metabolism)
• Nitric Oxide (metabolism)
• Plant Extracts (pharmacology)
• Plant Leaves (chemistry)
• Rats
• Rats, Wistar
• Stomach Ulcer (chemically induced, drug therapy)
• Tumor Necrosis Factor-alpha (blood)