Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.

Abstract

BACKGROUND:

The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.

METHODS:

Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.

RESULTS:

Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.

CONCLUSIONS:

Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.

• Authors: Gloria Pelizzo, Maria Chiara Mimmi, Maurizio Ballico, Mario Marotta, Ilaria Goruppi, Jose Louis Peiro, Elisa Zambaiti, Federico Costanzo, Erika Andreatta, Elena Tonin, Valeria Calcaterra
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 29 Issue 1 Pg. 143-7 ( 2016) ISSN: 1476-4954 [Electronic] England
• PMID: 25471172 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Humans
• Infant
• Infant, Newborn
• Lung (metabolism)
• Male
• Metabolome
• Phenotype
• Respiratory System Abnormalities (metabolism)