Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial.

Abstract

AIM:

The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP).

MATERIALS AND METHODS:

Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically administered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria.

RESULTS:

Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD ≥ 6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group.

CONCLUSIONS:

The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment.

• Authors: Carlos Martín Ardila, Juan Felipe Martelo-Cadavid, Gina Boderth-Acosta, Astrid Adriana Ariza-Garcés, Isabel C Guzmán
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 42 Issue 2 Pg. 160-8 (Feb 2015) ISSN: 1600-051X [Electronic] United States
• PMID: 25469723 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones
• Placebos
• Moxifloxacin

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (drug effects, isolation & purification)
• Aggressive Periodontitis (drug therapy, microbiology, therapy)
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Bacterial Load (drug effects)
• Bacteroides (drug effects, isolation & purification)
• Combined Modality Therapy
• Dental Plaque (microbiology)
• Dental Scaling (methods)
• Female
• Fluoroquinolones (administration & dosage, therapeutic use)
• Follow-Up Studies
• Gingival Hemorrhage (drug therapy, therapy)
• Humans
• Male
• Moxifloxacin
• Periodontal Attachment Loss (drug therapy, therapy)
• Periodontal Pocket (drug therapy, microbiology, therapy)
• Placebos
• Porphyromonas gingivalis (drug effects, isolation & purification)
• Root Planing (methods)
• Treatment Outcome
• Young Adult