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Pregnancy-associated plasma protein-A expression in human breast cancer.

AbstractOBJECTIVE:
Pregnancy-associated plasma protein-A (PAPP-A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. PAPP-A has been implicated in several cancers. However, studies of PAPP-A expression in breast cancer are limited. In this study, we assessed PAPP-A expression in different subtypes of human malignant breast cancer. Design Formalin-fixed paraffin-embedded tumor samples from 46 female patients with invasive breast cancer were divided into five defined groups [using markers for HER2, estrogen receptor, progesterone receptor, proliferation] that roughly correlate with molecularly defined subtypes (luminal A, luminal B, luminal/HER2 +, HER2 +, triple negative). These samples were analyzed for PAPP-A expression by immunohistochemistry.
RESULTS:
PAPP-A staining in tumor tissue was detected in 45 of 46 specimens. There were significantly greater extent and intensity of PAPP-A expression in luminal B specimens with high proliferation index than luminal A specimens (P = 0.01). However, there were no differences between specimens positive or negative for HER2 (P = 0.14) or positive and negative for estrogen receptor (P = 0.31).
CONCLUSION:
PAPP-A was detected in almost all breast cancer specimens and a more intense and greater extent of its expression was associated with luminal B specimens compared to luminal A specimens. The role of PAPP-A in breast cancer prognosis, and possibly therapeutics, warrants further investigation.
AuthorsAaron S Mansfield, Daniel W Visscher, Steven N Hart, Chen Wang, Matthew P Goetz, Claus Oxvig, Cheryl A Conover
JournalGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (Growth Horm IGF Res) Vol. 24 Issue 6 Pg. 264-7 (Dec 2014) ISSN: 1532-2238 [Electronic] Scotland
PMID25468445 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Biomarkers, Tumor
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Pregnancy-Associated Plasma Protein-A
  • PAPPA protein, human
Topics
  • Aged
  • Biomarkers, Tumor (metabolism)
  • Breast Neoplasms (metabolism, pathology)
  • Carcinoma, Ductal, Breast (metabolism, pathology)
  • Carcinoma, Lobular (metabolism, pathology)
  • Estrogen Receptor alpha (metabolism)
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Pregnancy
  • Pregnancy-Associated Plasma Protein-A (metabolism)
  • Prognosis
  • Receptors, Estrogen (metabolism)
  • Receptors, Progesterone (metabolism)

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