Abstract |
Bioaccumulation and effects of 17β-estradiol (E2) and 17α-ethynylestradiol (EE2) were assessed by crucian carp (Carassius auratus) following single and binary mixture exposures in flow-through exposure system for 16 months. In comparison with water control (DWC) and solvent control (SC), a significant reduction in body weight, body length and gonadosomatic index (GSI), and increase in hepatosomatic index (HSI) and plasma vitellogenin (VTG) levels were observed, in a time- and concentration-dependent manner. Bioconcentration factors (BCFs) of E2 and EE2 in fish muscle ranged from 3.2 to 40 and from 64 to 123, respectively. Crucian carp were found to be more sensitive to EE2 than E2. The bioaccumulation and toxicological effects in binary mixture exposed fish (mixture of E2 and EE2) were more significant than exposure of individual compound. Crucian carp is sensitive to E2 and EE2 in long-term laboratory exposure experiments and can be used as a potential model species for investigating the toxicity of hormones.
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Authors | Bin Huang, Wenwen Sun, Xiaoman Li, Jingliang Liu, Qiang Li, Renmin Wang, Xuejun Pan |
Journal | Ecotoxicology and environmental safety
(Ecotoxicol Environ Saf)
Vol. 112
Pg. 169-76
(Feb 2015)
ISSN: 1090-2414 [Electronic] Netherlands |
PMID | 25463868
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Estrogens
- Water Pollutants, Chemical
- Ethinyl Estradiol
- Estradiol
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Topics |
- Animals
- Carps
(blood, growth & development, physiology)
- Dose-Response Relationship, Drug
- Estradiol
(metabolism, toxicity)
- Estrogens
(metabolism, toxicity)
- Ethinyl Estradiol
(metabolism, toxicity)
- Female
- Time Factors
- Water Pollutants, Chemical
(metabolism, toxicity)
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