Evaluation of Mucorales DNA load in cerebrospinal fluid in a patient with possible cerebral mucormycosis treated with intravenous liposomal amphotericin B.

Abstract

We report the case of a 19-year-old male with possible cerebral mucormycosis following chemotherapy. We detected a Lichtheimia DNA load of 2.0×10(4) copies/ml in cerebrospinal fluid (CSF), although a CSF culture showed no growth. After treatment with intravenous liposomal amphotericin B, the Lichtheimia DNA load fell below the detection limit, and at the same time the patient's headache and imaging findings improved. The quantification of Mucorales DNA in CSF may be useful for evaluating cerebral mucormycosis.

• Authors: Tomonari Shigemura, Yozo Nakazawa, Kazuyuki Matsuda, Mitsuo Motobayashi, Shoji Saito, Kenichi Koike
• Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 29 Pg. 200-2 (Dec 2014) ISSN: 1878-3511 [Electronic] Canada
• PMID: 25461663 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

Chemical References

• Antifungal Agents
• DNA, Fungal
• liposomal amphotericin B
• Amphotericin B

Topics

• Adult
• Amphotericin B (administration & dosage, therapeutic use)
• Antifungal Agents (administration & dosage, therapeutic use)
• Brain Diseases (diagnosis, drug therapy, microbiology)
• DNA, Fungal (cerebrospinal fluid)
• Humans
• Male
• Mucorales (genetics)
• Mucormycosis (diagnosis, drug therapy, microbiology)
• Young Adult