A simple novel prognostic model for early stage oral tongue cancer.
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| Abstract |
The prognostication of patient outcome is one of the greatest challenges in the management of early stage oral tongue squamous cell carcinoma (OTSCC). This study introduces a simple histopathological model for the prognostication of survival in patients with early OTSCC. A total of 311 cases (from Finland and Brazil) with clinically evaluated early stage OTSCC (cT1-T2cN0cM0) were included in this multicentre retrospective study. Tumour budding (B) and depth of invasion (D) were scored on haematoxylin-eosin-stained cancer slides. The cut-off point for tumour budding was set at 5 buds (low <5; high ≥5) and for depth of invasion at 4mm (low <4mm; high ≥4mm). The scores of B and D were combined into one model: the BD predictive model. On multivariate analysis, a high risk score (BD score 2) correlated significantly with loco-regional recurrence (P=0.033) and death due to OTSCC (P<0.001) in early stage OTSCC. The new BD model is a promising prognostic tool to identify those patients with aggressive cases of early stage OTSCC who might benefit from multimodality treatment.
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| Authors | A Almangush, R D Coletta, I O Bello, C Bitu, H Keski-Säntti, L K Mäkinen, J H Kauppila, M Pukkila, J Hagström, J Laranne, S Tommola, Y Soini, V-M Kosma, P Koivunen, L P Kowalski, P Nieminen, R Grénman, I Leivo, T Salo |
| Journal | International journal of oral and maxillofacial surgery (Int J Oral Maxillofac Surg) Vol. 44 Issue 2 Pg. 143-50 (Feb 2015) ISSN: 1399-0020 [Electronic] Denmark |
| PMID | 25457829 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. |
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