Investigation of an outbreak of bloody diarrhea complicated with hemolytic uremic syndrome.
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| Abstract |
In July-August 2009, eight patients with bloody diarrhea complicated by hemolytic uremic syndrome (HUS) were admitted to hospitals in Tbilisi, Georgia. We started active surveillance in two regions for bloody diarrhea and post-diarrheal HUS. Of 25 case-patients who developed HUS, including the initial 8 cases, half were ⩾15 years old, 67% were female and seven (28%) died. No common exposures were identified. Among 20 HUS case-patients tested, Shiga toxin was detected in the stools of 2 patients (one with elevated serum IgG titers to several Escherichia coli serogroups, including O111 and O104). Among 56 persons with only bloody diarrhea, we isolated Shiga toxin-producing E. coli (STEC) O104:H4 from 2 and Shigella from 10; 2 had serologic evidence of E. coli O26 infection. These cases may indicate a previously unrecognized burden of HUS in Georgia. We recommend national reporting of HUS and improving STEC detection capacity.
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| Authors | Otar Chokoshvili, Khatuna Lomashvili, Naile Malakmadze, Marika Geleishvil, Jonas Brant, Paata Imnadze, Nazibrola Chitadze, Lia Tevzadze, Gvantsa Chanturia, Tea Tevdoradze, Tengiz Tsertsvadze, Deborah Talkington, Rajal K Mody, Nancy Strockbine, Russell A Gerber, Edmond Maes, Thomas Rush |
| Journal | Journal of epidemiology and global health (J Epidemiol Glob Health) Vol. 4 Issue 4 Pg. 249-59 (Dec 2014) ISSN: 2210-6014 [Electronic] Switzerland |
| PMID | 25455642 (Publication Type: Journal Article) |
| Copyright | Copyright © 2014 Ministry of Health, Saudi Arabia. All rights reserved. |
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