How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors.

Abstract	SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.
Authors	Carmen Ruggiero, Mabrouka Doghman, Enzo Lalli
Journal	Molecular and cellular endocrinology (Mol Cell Endocrinol) Vol. 408 Pg. 138-44 (Jun 15 2015) ISSN: 1872-8057 [Electronic] Ireland
PMID	25449416 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright	Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Chemical References	Receptors, Cytoplasmic and Nuclear
Topics	Animals Gene Expression Regulation Genomics Humans Models, Genetic Organ Specificity (genetics) Receptors, Cytoplasmic and Nuclear (metabolism) Transcription, Genetic

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