Abstract |
SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.
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Authors | Carmen Ruggiero, Mabrouka Doghman, Enzo Lalli |
Journal | Molecular and cellular endocrinology
(Mol Cell Endocrinol)
Vol. 408
Pg. 138-44
(Jun 15 2015)
ISSN: 1872-8057 [Electronic] Ireland |
PMID | 25449416
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Receptors, Cytoplasmic and Nuclear
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Topics |
- Animals
- Gene Expression Regulation
- Genomics
- Humans
- Models, Genetic
- Organ Specificity
(genetics)
- Receptors, Cytoplasmic and Nuclear
(metabolism)
- Transcription, Genetic
|