Abstract | PURPOSE: METHODS: The signal intensities of the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles were measured using the STIR images from 34 eyes of 17 patients with TAO before and after methylprednisolone pulse therapy and 19 eyes of 19 controls. The signal intensity ratio (SIR) of the signal intensity in muscles to that in brain white matter was calculated. RESULTS: The mean SIRs of the controls were 1.08 ± 0.26 in the SR, 1.32 ± 0.29 in the IR, 1.34 ± 0.19 in the LR, 1.47 ± 0.25 in the MR, and 1.28 ± 0.22 in the SO muscles. SIRs exceeding 2.0 were out of the normal range. The SIRs of the patients with TAO before treatment were 2.19 ± 0.64, 2.44 ± 0.58, 1.96 ± 0.43, 2.24 ± 0.47, and 1.91 ± 0.42, respectively, which was significantly (P < 0.001) higher than those of the controls; after treatment, the mean SIRs were 1.82 ± 0.57, 1.81 ± 0.49, 1.64 ± 0.35, 1.88 ± 0.43, and 1.54 ± 0.33, respectively, significantly (P < 0.001) lower in all muscles than those before treatment. However, the SIRs of some muscles remained over 2.0. Moreover, all cases that had deterioration of TAO had one or more muscles with a SIR exceeding 2.5 after treatment. CONCLUSION:
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Authors | Tomoaki Higashiyama, Yasuhiro Nishida, Katsutaro Morino, Satoshi Ugi, Yoshihiko Nishio, Hiroshi Maegawa, Masahito Ohji |
Journal | Japanese journal of ophthalmology
(Jpn J Ophthalmol)
Vol. 59
Issue 2
Pg. 124-30
(Mar 2015)
ISSN: 1613-2246 [Electronic] Japan |
PMID | 25448468
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Glucocorticoids
- Prednisolone
- Methylprednisolone
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Topics |
- Administration, Oral
- Adult
- Aged
- Diplopia
(physiopathology)
- Female
- Glucocorticoids
(administration & dosage)
- Graves Ophthalmopathy
(drug therapy, physiopathology)
- Humans
- Magnetic Resonance Imaging
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Oculomotor Muscles
(pathology)
- Prednisolone
(administration & dosage)
- Pulse Therapy, Drug
- Young Adult
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