Abstract |
In the present study, the effects of bilateral injections of dopaminergic drugs into the hippocampal CA1 regions (intra-CA1) on harmaline-induced amnesia were examined in male mice. A one-trial step-down passive avoidance task was used for the assessment of memory retention in adult male mice. Pre-training intra-peritoneal (i.p.) administration of harmaline (1 mg/kg) induced impairment of memory retention. Moreover, intra-CA1 administration of dopamine D1 receptor antagonist, SCH23390 (0.02 μg/mouse), dopamine D1 receptor agonist, SKF38393 (0.5 μg/mouse), dopamine D2 receptor antagonist, sulpiride (1 μg/mouse) and dopamine D2 receptor agonist, quinpirole (0.25 and 0.5 μg/mouse) suppressed the learning of a single-trial passive avoidance task. Also, pre-training intra-CA1 injection of subthreshold doses of SCH23390 (0.001 μg/mouse) or sulpiride (0.25 μg/mouse) with the administration of harmaline (1 mg/kg, i.p.) reversed impairment of memory formation. However, pre-training intra-CA1 injection of SKF38393 (0.1 μg/mouse) or quinpirole (0.1 μg/mouse) increased pre-training harmaline (0.25 and 0.5 mg/kg, i.p.)-induced retrieval impairment. Moreover, SKF Ca blocker (SKF) (0.01 μg/mouse) decrease the amnesia induced by harmaline (1 mg/kg), while co-administration of SKF (0.01 μg/mouse)/ sulpiride (0.25 μg/mouse) or SCH23390 (0.001 μg/mouse)/ sulpiride (0.25 μg/mouse) potentiate amnesia caused by harmaline. These findings implicate the involvement of CA1 dopaminergic mechanism in harmaline-induced impairment of memory acquisition.
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Authors | M Nasehi, M Ketabchi, F Khakpai, M-R Zarrindast |
Journal | Neuroscience
(Neuroscience)
Vol. 285
Pg. 47-59
(Jan 29 2015)
ISSN: 1873-7544 [Electronic] United States |
PMID | 25446354
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Benzazepines
- Dopamine Agonists
- Dopamine Antagonists
- Monoamine Oxidase Inhibitors
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- SCH 23390
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
- Sulpiride
- Harmaline
- Dopamine
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Topics |
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
(pharmacology)
- Amnesia
(chemically induced, drug therapy, metabolism)
- Animals
- Avoidance Learning
(drug effects, physiology)
- Benzazepines
(pharmacology)
- CA1 Region, Hippocampal
(drug effects, metabolism)
- Dopamine
(metabolism)
- Dopamine Agonists
(pharmacology)
- Dopamine Antagonists
(pharmacology)
- Harmaline
(toxicity)
- Male
- Memory
(drug effects, physiology)
- Mice
- Monoamine Oxidase Inhibitors
(toxicity)
- Receptors, Dopamine D1
(metabolism)
- Receptors, Dopamine D2
(metabolism)
- Sulpiride
(pharmacology)
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