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Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.

Abstract
Ubiquitin-specific peptidase 22 (USP22) was recently identified as a new tumor cell marker, and previous studies demonstrated its expression in a variety of tumors and its correlation with tumor progression. Because tumor progression plays an important role in cancer, researchers are paying more attention to the correlation between USP22 expression and metastatic potential, resistance to chemotherapy, and patient prognosis. This study showed that USP22 is highly expressed in gastric cancer tissues, and significant differences in USP22 expression (P < 0.01) were identified between different types of gastric cancer (the highest expression was found in poorly differentiated adenocarcinomas). In addition USP22 expression was found to be correlated with the promotion of cancer evolution, tumor invasion, and lymph node metastasis. The C-myc protein was also shown to have synergistic effects with USP22 in gastric cancer tissue. On the basis of the results, USP22 expression may play an important role in gastric carcinoma tissue, particularly in precancerous lesions during the gastric cancer evolution process.
AuthorsYan He, Yin-Ji Jin, Yu-Hua Zhang, Hong-Xue Meng, Bao-Shan Zhao, Yang Jiang, Ji-Wei Zhu, Guan-Ying Liang, Dan Kong, Xiao-Ming Jin
JournalTranslational research : the journal of laboratory and clinical medicine (Transl Res) Vol. 165 Issue 3 Pg. 407-16 (Mar 2015) ISSN: 1878-1810 [Electronic] United States
PMID25445209 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Proto-Oncogene Proteins c-myc
  • Thiolester Hydrolases
  • Ubiquitin Thiolesterase
  • Usp22 protein, human
Topics
  • Adult
  • Disease Progression
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Male
  • Middle Aged
  • Paraffin Embedding
  • Prognosis
  • Proto-Oncogene Proteins c-myc (metabolism)
  • Stomach Neoplasms (enzymology, pathology)
  • Thiolester Hydrolases (metabolism)
  • Ubiquitin Thiolesterase

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