Abstract | AIM: METHODS: RESULTS: Serum TC and TBA levels were correlated in the AGS patients. Liver cholesterol was also increased compared with controls, and correlated with bile acid contents. LDLR, SR-BI, HMGCR, and ABCGs mRNA expression were upregulated, while CYP7A1 mRNA expression was downregulated in AGS livers. SHP and LXRα mRNA expression was also increased, but maturation of SREBP2 was not suppressed in the patients. CONCLUSIONS: The major upregulators of liver cholesterol might be increased in AGS patients, indicating an impaired negative feedback mechanism and accelerated liver cholesterol accumulation.
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Authors | Yuki Miyahara, Kazuhiko Bessho, Hiroki Kondou, Yasuhiro Hasegawa, Kie Yasuda, Shinobu Ida, Yoshiyuki Ihara, Koichi Mizuta, Yoko Miyoshi, Keiichi Ozono |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 440
Pg. 49-54
(Feb 02 2015)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 25444747
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Bile Acids and Salts
- LDLR protein, human
- Receptors, LDL
- SCARB1 protein, human
- SREBF2 protein, human
- Scavenger Receptors, Class B
- Sterol Regulatory Element Binding Protein 2
- Cholesterol
- HMGCR protein, human
- Hydroxymethylglutaryl CoA Reductases
- CYP7A1 protein, human
- Cholesterol 7-alpha-Hydroxylase
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Topics |
- Adolescent
- Alagille Syndrome
(metabolism, physiopathology)
- Bile Acids and Salts
(metabolism)
- Case-Control Studies
- Child
- Child, Preschool
- Cholesterol
(metabolism)
- Cholesterol 7-alpha-Hydroxylase
(genetics, metabolism)
- Feedback, Physiological
- Female
- Humans
- Hydroxymethylglutaryl CoA Reductases
(genetics, metabolism)
- Hypercholesterolemia
(genetics, metabolism)
- Infant
- Liver
(metabolism, pathology)
- Male
- Receptors, LDL
(genetics, metabolism)
- Scavenger Receptors, Class B
(genetics, metabolism)
- Sterol Regulatory Element Binding Protein 2
(genetics, metabolism)
- Young Adult
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