[Infliximab is effective in difficult-to-control peripheral ulcerative keratitis. A report of three cases].

Abstract

Peripheral ulcerative keratitis is caused by an inflammatory and destructive process of the perilimbal peripheral cornea. This inflammation is due to immune complex deposition in this region of the cornea and in adjacent vessels. It can be idiopathic, or a manifestation of systemic disease such as rheumatoid arthritis, vasculitis of small vessels associated with ANCA, relapsing polychondritis, systemic lupus erythematosus and Crohn's disease. Its treatment includes the use of high-dose corticosteroids and, in some cases, the concomitant use of immunosuppressants such as methotrexate, azathioprine, mycophenolate mofetil, cyclophosphamide or cyclosporine. The use of immunobiological agents can be a strategy in cases of difficult control. The authors describe the treatment of three patients who, after failure with the use of corticosteroids or immunosuppressants, showed good response after the use of infliximab.

• Authors: Flávia Maria Zandavalli, Glaucio Ricardo Werner de Castro, Maiara Mazzucco, Maria Eduarda Carvalho Wagnes Stöfler, Ivânio Alves Pereira
• Journal: Revista brasileira de reumatologia (Rev Bras Reumatol) 2015 May-Jun Vol. 55 Issue 3 Pg. 310-2 ISSN: 1809-4570 [Electronic] Brazil
• Vernacular Title: Infliximabe é eficaz em ceratite ulcerada periférica de difícil controle. Um relato de três casos.
• PMID: 25440698 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Editora Ltda. All rights reserved.

Chemical References

• Infliximab

Topics

• Adult
• Corneal Ulcer (drug therapy)
• Female
• Humans
• Infliximab (therapeutic use)
• Male
• Middle Aged
• Remission Induction
• Young Adult