Abstract | OBJECTIVE: DESIGN: Prospective, interventional study. SETTING: Research laboratory, single institution. PARTICIPANTS: Twenty-four New Zealand white rabbits. INTERVENTIONS: Twenty-four rabbits were divided into 3 equal groups: group I ( sham), group II ( ischemia-reperfusion, control group), and group III ( cilostazol, administered orally 30 mg/kg/day for 3 days before the surgery). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the iliac bifurcation for 30 minutes. Seventy-two hours postoperatively, the motor function of the lower limbs was evaluated in each animal according to the modified Tarlov score. Spinal cord and blood samples were taken for histopathologic and biochemical analyses at the 72nd hour of reperfusion. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: This study showed that pretreatment with cilostazol significantly ameliorated neurologic functional outcome and attenuated neuronal histopathologic injury after transient aortic occlusion in rabbits.
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Authors | Yunus Nazli, Necmettin Colak, Mehmet Namuslu, Husamettin Erdamar, Hacer Haltas, Mehmet Fatih Alpay, Omer Nuri Aksoy, Ismail Olgun Akkaya, Omer Cakir |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 29
Issue 2
Pg. 351-9
(Apr 2015)
ISSN: 1532-8422 [Electronic] United States |
PMID | 25440635
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Phosphodiesterase 3 Inhibitors
- Tetrazoles
- Cilostazol
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Topics |
- Animals
- Cilostazol
- Disease Models, Animal
- Phosphodiesterase 3 Inhibitors
(therapeutic use)
- Prospective Studies
- Rabbits
- Reperfusion Injury
(drug therapy, pathology)
- Spinal Cord Ischemia
(drug therapy, pathology)
- Tetrazoles
(therapeutic use)
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