Clinical remission of psoriatic arthritis in patients receiving continuous biological therapies for 1 year: the experience of an outpatient dermatological clinic for psoriasis.

Abstract

BACKGROUND:

The data in the literature concerning the frequency of remission of inflammatory arthritis in patients with psoriatic arthritis (PsA) are limited and conflicting.

AIM:

To evaluate the frequency of clinical remission in inflammatory arthritis in a cohort of patients with PsA receiving continuous treatment (1 year) with tumour necrosis factor-α inhibitors or ustekinumab, as well as the clinical covariates affecting remission.

METHODS:

We retrospectively evaluated 74 patients with PsA attending our psoriasis outpatient dermatology clinic. Remission of PsA was defined as documented absence of clinical signs related to arthritis (no tender or swollen joints), enthesitis or dactylitis. Patients were examined every 3 months for 1 year.

RESULTS:

At 1 year > 40% of patients had clinical remission of inflammatory arthritis. Predictors of remission were absence of fibromyalgia (FM) at baseline and having < 11 tender joints.

CONCLUSIONS:

Clinical remission of inflammatory arthritis can be obtained in a significant proportion of patients by continuous treatment with biological drugs. A large number of tender joints and the presence of FM can make remission less likely.

• Authors: D Graceffa, E Maiani, I Sperduti, F Ceralli, C Bonifati
• Journal: Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 40 Issue 2 Pg. 136-41 (Mar 2015) ISSN: 1365-2230 [Electronic] England
• PMID: 25438647 (Publication Type: Journal Article)
• Copyright: © 2014 British Association of Dermatologists.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antibodies, Monoclonal
• Antirheumatic Agents
• Biological Factors
• Immunologic Factors
• Tumor Necrosis Factor-alpha

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antirheumatic Agents (therapeutic use)
• Arthritis, Psoriatic (drug therapy)
• Biological Factors (therapeutic use)
• Biological Therapy (methods)
• Female
• Humans
• Immunologic Factors (therapeutic use)
• Male
• Middle Aged
• Retrospective Studies
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)