Accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking as a first-line and sole treatment in early fungal keratitis.

Abstract

PURPOSE:

To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis.

METHODS:

Case report and literature review.

RESULTS:

A patient who presented with a painful peripheral corneal infiltrate underwent PACK-CXL with a local limited abrasion and accelerated ultraviolet-A irradiation at 365 μm and 9 mW/cm² for 10 minutes. Cultures grew Aureobasidium pullulans. The corneal epithelium closed completely within 3 days and the infiltrate was completely eradicated without administration of antibiotics.

CONCLUSIONS:

Accelerated PACK-CXL was successfully used as a first-line and sole treatment in a case of early fungal keratitis caused by Aureobasidium pullulans. Further characterization of the antifungal effect of PACK-CXL is needed in prospective studies.

• Authors: David Tabibian, Olivier Richoz, Arnaud Riat, Jacques Schrenzel, Farhad Hafezi
• Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) (J Refract Surg) Vol. 30 Issue 12 Pg. 855-7 (Dec 2014) ISSN: 1081-597X [Print] United States
• PMID: 25437486 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2014, SLACK Incorporated.

Chemical References

• Cross-Linking Reagents
• Photosensitizing Agents
• Collagen
• Riboflavin

Topics

• Adult
• Ascomycota (isolation & purification)
• Collagen (metabolism)
• Corneal Stroma (metabolism)
• Corneal Ulcer (drug therapy, metabolism, microbiology)
• Cross-Linking Reagents (therapeutic use)
• Eye Infections, Fungal (drug therapy, metabolism, microbiology)
• Female
• Humans
• Mycoses (drug therapy, metabolism, microbiology)
• Photochemotherapy (methods)
• Photosensitizing Agents (therapeutic use)
• Riboflavin (therapeutic use)
• Tomography, Optical Coherence
• Visual Acuity