Abstract | CONTEXT: OBJECTIVE: The present study seeks to develop a simple mouse model of NAFLD-enhanced skin inflammation and to study the effect of NAFLD on different parameters of skin inflammation. MATERIALS AND METHOD: RESULTS: HFD and HFL diet induced obesity, hyperglycemia, hyperinsulinemia, and histological features of NAFLD in mice. Oxazolone challenge significantly increased ear thickness, ear weight, MPO activity, NF-κB activity, and histological features of skin inflammation in NAFLD mice as compared with normal mice. Overall, induction of oxazolone-induced skin inflammation was more prominent in NAFLD mice than normal mice. Hence, HFD and HFL diet followed by topical oxazolone application develops metabolic syndrome, NAFLD, and enhanced skin inflammation in mice. DISCUSSION AND CONCLUSION: This simple model can be utilized to evaluate a therapeutic strategy for the treatment of metabolic syndrome and NAFLD with skin inflammation and also to understand the nexus between these co-morbidities.
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Authors | Nagaraj M Kulkarni, Mallikarjun S Jaji, Pranesha Shetty, Yeshwant V Kurhe, Shilpee Chaudhary, G Vijaykant, J Raghul, Santosh L Vishwakarma, B Navin Rajesh, Jeyamurugan Mookkan, Uma Maheswari Krishnan, Shridhar Narayanan |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 53
Issue 8
Pg. 1110-7
(Aug 2015)
ISSN: 1744-5116 [Electronic] England |
PMID | 25430922
(Publication Type: Journal Article)
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Topics |
- Animals
- Dermatitis
(etiology, metabolism, pathology)
- Diet, High-Fat
(adverse effects)
- Disease Models, Animal
- Male
- Metabolic Syndrome
(etiology, metabolism, pathology)
- Mice
- Mice, Inbred C57BL
- Non-alcoholic Fatty Liver Disease
(complications, metabolism, pathology)
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