Abstract |
The ability of thiol and non- thiol radioprotectors to induce hypoxia was determined using the binding of [3H] misonidazole by bone marrow cells as a measure of hypoxia. When administered at maximally radioprotective doses, four drugs ( WR-2721, cysteamine, 5-hydroxytryptamine, and 16,16-dimethyl prostaglandin E2) significantly increased the amount of [3H] misonidazole bound by marrow cells, while no significant increase in binding was observed with three other agents ( endotoxin, AET, superoxide dimutase). Doses of WR-2721 previously shown to provide suboptimal radioprotection did not significantly increase 3H-misonidazole binding. These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo.
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Authors | M J Allalunis-Turner, T L Walden Jr, C Sawich |
Journal | Radiation research
(Radiat Res)
Vol. 118
Issue 3
Pg. 581-6
(Jun 1989)
ISSN: 0033-7587 [Print] United States |
PMID | 2543028
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Endotoxins
- Radiation-Protective Agents
- beta-Aminoethyl Isothiourea
- Serotonin
- Cysteamine
- Superoxide Dismutase
- Amifostine
- 16,16-Dimethylprostaglandin E2
- Oxygen
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Topics |
- 16,16-Dimethylprostaglandin E2
(pharmacology)
- Amifostine
(pharmacology)
- Animals
- Bone Marrow
(metabolism)
- Bone Marrow Cells
- Cysteamine
(pharmacology)
- Endotoxins
(pharmacology)
- Female
- Mice
- Mice, Inbred BALB C
- Oxygen
(metabolism)
- Radiation-Protective Agents
(pharmacology)
- Serotonin
(pharmacology)
- Superoxide Dismutase
(pharmacology)
- beta-Aminoethyl Isothiourea
(pharmacology)
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