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Induction of marrow hypoxia by radioprotective agents.

Abstract
The ability of thiol and non-thiol radioprotectors to induce hypoxia was determined using the binding of [3H]misonidazole by bone marrow cells as a measure of hypoxia. When administered at maximally radioprotective doses, four drugs (WR-2721, cysteamine, 5-hydroxytryptamine, and 16,16-dimethyl prostaglandin E2) significantly increased the amount of [3H]misonidazole bound by marrow cells, while no significant increase in binding was observed with three other agents (endotoxin, AET, superoxide dimutase). Doses of WR-2721 previously shown to provide suboptimal radioprotection did not significantly increase 3H-misonidazole binding. These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo.
AuthorsM J Allalunis-Turner, T L Walden Jr, C Sawich
JournalRadiation research (Radiat Res) Vol. 118 Issue 3 Pg. 581-6 (Jun 1989) ISSN: 0033-7587 [Print] United States
PMID2543028 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Endotoxins
  • Radiation-Protective Agents
  • beta-Aminoethyl Isothiourea
  • Serotonin
  • Cysteamine
  • Superoxide Dismutase
  • Amifostine
  • 16,16-Dimethylprostaglandin E2
  • Oxygen
Topics
  • 16,16-Dimethylprostaglandin E2 (pharmacology)
  • Amifostine (pharmacology)
  • Animals
  • Bone Marrow (metabolism)
  • Bone Marrow Cells
  • Cysteamine (pharmacology)
  • Endotoxins (pharmacology)
  • Female
  • Mice
  • Mice, Inbred BALB C
  • Oxygen (metabolism)
  • Radiation-Protective Agents (pharmacology)
  • Serotonin (pharmacology)
  • Superoxide Dismutase (pharmacology)
  • beta-Aminoethyl Isothiourea (pharmacology)

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