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Parthenolide could become a promising and stable drug with anti-inflammatory effects.

Abstract
The aim of this paper is to summarise the blocking effects of parthenolide on the cytokines and pathways that cause inflammation. Analyses of the chemical structure of parthenolide have tried to identify the active domains that play key roles in its anti-inflammatory activity. This review focuses on the anti-inflammatory actions of parthenolide in both in vitro and in vivo. These data will be helpful for future investigations into the effects of parthenolide on inflammation.
AuthorsMengting Wang, Qiyan Li
JournalNatural product research (Nat Prod Res) Vol. 29 Issue 12 Pg. 1092-101 ( 2015) ISSN: 1478-6427 [Electronic] England
PMID25429885 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • Sesquiterpenes
  • parthenolide
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Cytokines (metabolism)
  • Humans
  • Inflammation (drug therapy)
  • Sesquiterpenes (pharmacology)

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