Abstract | AIM: To evaluate the efficacy of a 2-week administration of a 0.1% chlorhexidine mouthwash in the short-term treatment of chronic periodontitis patients and the impact of this product when administered twice by pocket irrigation. METHODS: Sixty patients were enrolled in a single-centre, placebo-controlled, randomized study with the blind allocation of product to two parallel groups. Clinical assessments were performed, and samples from six selected subgingival sites were collected for microbial analysis by culture at baseline, D15 and D56. Three of the six sites were randomly selected and were treated by subgingival irrigation with the same 0.1% chlorhexidine product at D0 and D7. A subsequent statistical analysis was performed using the paired Student's t-test and Wilcoxon rank sum test for within-group analyses; analysis of variance and the Kruskall-Wallis test were used for between-group analyses. RESULTS: Two-week treatment with a 0.1% chlorhexidine mouthwash slightly reduced the gingival inflammation associated with periodontitis. We observed a significant decrease in Gram-negative, facultative anaerobes and micro-aerophiles, and a significant increase in Gram-positive cocci. No increase in the treatment effect was demonstrated by irrigation of the periodontal pockets. CONCLUSION:
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Authors | Henri Tenenbaum, Jöelle Luc, Jean-François Schaaf, Marie Federlin-Ducani, Christine Cotton, René Elkaim, Frédéric J G Cuisinier, Christine Roques |
Journal | Journal of investigative and clinical dentistry
(J Investig Clin Dent)
Vol. 2
Issue 1
Pg. 29-37
(Feb 2011)
ISSN: 2041-1626 [Electronic] Australia |
PMID | 25427325
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 Blackwell Publishing Asia Pty Ltd. |
Chemical References |
- Mouthwashes
- Placebos
- Chlorhexidine
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Topics |
- Administration, Topical
- Adult
- Aged
- Bacterial Load
(drug effects)
- Chlorhexidine
(administration & dosage, therapeutic use)
- Chronic Periodontitis
(drug therapy, microbiology)
- Dental Plaque Index
- Female
- Follow-Up Studies
- Gingivitis
(drug therapy)
- Gram-Negative Aerobic Bacteria
(drug effects)
- Gram-Negative Anaerobic Bacteria
(drug effects)
- Gram-Positive Cocci
(drug effects)
- Gram-Positive Rods
(drug effects)
- Humans
- Male
- Middle Aged
- Mouthwashes
(administration & dosage, therapeutic use)
- Periodontal Index
- Periodontal Pocket
(drug therapy, microbiology)
- Placebos
- Porphyromonas
(drug effects)
- Therapeutic Irrigation
(methods)
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