Abstract | INTRODUCTION: METHODS: Twenty male subjects were treated in a randomized double-blind fashion with the investigational medicinal product (IMPD) and vehicle. Immediately after the injection of 100 µg histamine on both arms, subjects received topical treatment and pruritus was subsequently assessed with visual analogue scale (VASpruritus) and Eppendorfer questionnaire. Ultraviolet B radiation (UVB) was administered on the back to induce slight sunburn. Twelve hours after UVB application again the IMPD was applied on the right or left upper back and vehicle on the other side and pain related to sunburn was measured with VASpain and pressure algometry. RESULTS: A trend towards better reduction of pruritus was shown for benzocaine in VASpruritus. For the VASpain significant differences in group comparison (p = 0.02) were observed. Algometer measurements showed onset of pain reduction in the verum group after 20 min whereas in the vehicle-treated area pain relief occurred only after 60 min after application. CONCLUSIONS:
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Authors | Martin Bauer, Richard Schwameis, Thomas Scherzer, Isabelle Lang-Zwosta, Kanako Nishino, Markus Zeitlinger |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 26
Issue 4
Pg. 367-72
( 2015)
ISSN: 1471-1753 [Electronic] England |
PMID | 25424049
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ointments
- Histamine
- Benzocaine
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Topics |
- Administration, Topical
- Adult
- Benzocaine
(administration & dosage)
- Double-Blind Method
- Histamine
(administration & dosage)
- Humans
- Male
- Ointments
(therapeutic use)
- Pain
(drug therapy)
- Pain Measurement
- Pruritus
(drug therapy)
- Sunburn
(drug therapy)
- Ultraviolet Rays
(adverse effects)
- Young Adult
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