Abstract | INTRODUCTION: METHODS: A 24-year-old female admitted with generalized seizure, lethargy, but no focal neurological signs. Head scans revealed right frontal hypodensity with loss of basal cisterns, mild transfalcine shift to the left, a mass lesion with abnormal signal and multiple small hemorrhages. Biopsy pathology showed white matter demyelinating lesions with necrotizing destruction of small vessels and acute inflammation. EMG was consistent with demyelinating diffuse polyneuropathy and myopathy. Pathology of muscle showed myopathic changes suggestive of autoimmune myopathy. RESULTS: CONCLUSION:
Acute hemorrhagic leukoencephalitis is a rare and usually fatal disorder. The etiology of AHLE remains clear; cross-reactivity between human myelin antigens and viral or bacterial antigens is thought to initiate an immune process causing demyelination. Usually the autoimmune process targets CNS myelin and spares the peripheral; however, in this case there was diffuse involvement of central and peripheral myelin and muscle.
|
Authors | |
Journal | Journal of vascular and interventional neurology
(J Vasc Interv Neurol)
Vol. 7
Issue 4
Pg. 19-22
(Nov 2014)
ISSN: 1941-5893 [Print] United States |
PMID | 25422709
(Publication Type: Journal Article)
|