Abstract | OBJECTIVE:
Ecabet sodium (ES) is a new non-systemic anti- ulcer agent belonging to the category of gastroprotective agents. In this study we aimed to compare the efficacy of a combination therapy with lansoprazole (LS) followed by ES with LS alone in treating endoscopic submucosal dissection (ESD)-induced iatrogenic gastric ulcers. METHODS: Patients diagnosed with gastric adenomas or early gastric cancer were randomly divided into either the LS group (30 mg once daily for 4 weeks; n = 45) or the LS + ES group (LS 30 mg once daily for one week followed by ES 1500 mg twice daily for 3 weeks; n = 45). Four weeks after ESD, a follow-up endoscopy was conducted to evaluate the proportions of ulcer reduction and ulcer stages in the two groups. RESULTS: In all, 79 patients were included in the final analyses. Both treatment modalities were well-tolerated in most patients, with a drug compliance of over 80%. There were no significant differences between the two groups in terms of the proportions of ulcer reduction (0.9503 ± 0.1215 in the LS group vs 0.9192 ± 0.0700 in the LS + ES group, P = 0.169) or ulcer stage (P = 0.446). The prevalence of adverse events related to drugs and bleeding were also similar between the two groups. CONCLUSION:
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Authors | Ji Yong Ahn, Chang Hwan Choi, Jang Wook Lee, Sung Jin Park, Jeong Wook Kim, Sae Kyung Chang, Seung Bong Han |
Journal | Journal of digestive diseases
(J Dig Dis)
Vol. 16
Issue 2
Pg. 75-82
(Feb 2015)
ISSN: 1751-2980 [Electronic] Australia |
PMID | 25420889
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Abietanes
- Anti-Ulcer Agents
- Lansoprazole
- ecabet
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Topics |
- Abietanes
(administration & dosage)
- Aged
- Anti-Ulcer Agents
(administration & dosage)
- Dissection
(adverse effects)
- Drug Therapy, Combination
- Endoscopy, Gastrointestinal
(methods)
- Female
- Gastric Mucosa
(surgery)
- Humans
- Iatrogenic Disease
- Lansoprazole
(administration & dosage)
- Male
- Middle Aged
- Prospective Studies
- Random Allocation
- Stomach Neoplasms
(surgery)
- Stomach Ulcer
(drug therapy, etiology)
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