HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epigenetic regulation of acute inflammatory pain.

Abstract
Acute pain is associated with tissue damage, which results in the release of inflammatory mediators. Recent studies point to the involvement of epigenetic mechanisms (DNA methylation) in the development of pain. We have found that during acute inflammatory pain induced by the application of 10% mustard oil on the tongues of rats, levels of DNMT3a and 3b were elevated markedly (36 and 42 % respectively), whereas the level of DNMT1 was not changed significantly. Previous injection of Xefocam with 0,4 mg/kg dose decreased levels of DNMT3a and 3b (25 and 24% respectively). The level of DNMT1 was not changed significantly compared to the control group. The findings support the idea that inhibitors of DNA-methyltransferases could be useful for pain management. Our data suggest that NSAIDs (alone or in combination with DNMT inhibitors) may be proposed as possible epigenetic regulatory agents, which may play a role in epigenetic mechanisms indirectly through altering the activity of inflammatory mediators involved in pain development.
AuthorsE Abzianidze, E Kvaratskhelia, T Tkemaladze, K Kankava, G Gurtskaia, M Tsagareli
JournalGeorgian medical news (Georgian Med News) Issue 235 Pg. 78-81 (Oct 2014) ISSN: 1512-0112 [Print] Georgia (Republic)
PMID25416223 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Oils
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
  • DNA methyltransferase 3B
  • Dnmt1 protein, rat
  • mustard oil
Topics
  • Acute Pain (drug therapy, genetics, physiopathology)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • DNA (Cytosine-5-)-Methyltransferase 1
  • DNA (Cytosine-5-)-Methyltransferases (biosynthesis)
  • DNA Methylation (genetics)
  • DNA Methyltransferase 3A
  • Epigenesis, Genetic
  • Gene Expression Regulation (drug effects)
  • Inflammation (drug therapy, genetics, physiopathology)
  • Mustard Plant
  • Plant Oils (administration & dosage)
  • Rats
  • Tongue (drug effects, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: