Abstract | OBJECTIVE: DESIGN AND SETTING: A cross-sectional study involving 85 PCOS (48 obese) and 72 non-PCOS women (41 obese) was conducted to evaluate the relationship between FGF21 levels and PCOS. METHODS: Anthropometric parameters and body composition were determined. In the fasting state; serum concentrations of glucose, androgens, FSH, LH, SHBG, insulin and FGF21 were measured. RESULTS: Plasma FGF21 levels were significantly higher in obese women compared with normal-weight women in both PCOS and non-PCOS subgroups (120.3 (18.2-698) vs 62.3 (16.4-323.6) pg/ml, P<0.05 and 87.2 (12.9-748.4) vs 62.9 (18.0-378.8) pg/ml, P<0.05 respectively). Additionally, circulating FGF21 levels were significantly higher in the obese PCOS subgroup compared with the non-PCOS subgroup (120.3 (18.2-698.0) vs 87.2 (12.9-748.4) pg/ml, P<0.05). Circulating FGF21 levels were proportional to BMI (R=0.27; P<0.001), body fat mass (R=0.24; P<0.01) and percentage (R=0.24; P<0.01), as well as waist circumference (R=0.26; P<0.01). Additionally, plasma insulin and homeostasis model assessment of insulin resistance (HOMA-IR) values were related to FGF21 levels (R=0.44; P<0.001 and R=0.19; P<0.05 respectively). In multiple regression analysis, circulating FGF21 level variability was explained by HOMA-IR values and fat percentage, as well as waist circumference, but not correlated with oestradiol levels and free androgen index values. CONCLUSIONS: Higher circulating FGF21 levels are related to nutritional status and insulin resistance independent of PCOS. Increased FGF21 is associated with metabolic but not hormonal disturbances.
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Authors | Magdalena Olszanecka-Glinianowicz, Paweł Madej, Michał Wdowczyk, Aleksander Owczarek, Jerzy Chudek |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 172
Issue 2
Pg. 173-9
(Feb 2015)
ISSN: 1479-683X [Electronic] England |
PMID | 25411238
(Publication Type: Journal Article)
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Copyright | © 2015 European Society of Endocrinology. |
Chemical References |
- Biomarkers
- fibroblast growth factor 21
- Fibroblast Growth Factors
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Topics |
- Adult
- Biomarkers
(blood)
- Cross-Sectional Studies
- Female
- Fibroblast Growth Factors
(blood)
- Humans
- Insulin Resistance
(physiology)
- Nutritional Status
(physiology)
- Obesity
(blood, diagnosis)
- Polycystic Ovary Syndrome
(blood, diagnosis)
- Prospective Studies
- Young Adult
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