Nanoscale metal-organic framework for highly effective photodynamic therapy of resistant head and neck cancer.

Abstract

Photodynamic therapy (PDT) is an effective anticancer procedure that relies on tumor localization of a photosensitizer followed by light activation to generate cytotoxic reactive oxygen species (e.g., (1)O2). Here we report the rational design of a Hf-porphyrin nanoscale metal-organic framework, DBP-UiO, as an exceptionally effective photosensitizer for PDT of resistant head and neck cancer. DBP-UiO efficiently generates (1)O2 owing to site isolation of porphyrin ligands, enhanced intersystem crossing by heavy Hf centers, and facile (1)O2 diffusion through porous DBP-UiO nanoplates. Consequently, DBP-UiO displayed greatly enhanced PDT efficacy both in vitro and in vivo, leading to complete tumor eradication in half of the mice receiving a single DBP-UiO dose and a single light exposure. NMOFs thus represent a new class of highly potent PDT agents and hold great promise in treating resistant cancers in the clinic.

• Authors: Kuangda Lu, Chunbai He, Wenbin Lin
• Journal: Journal of the American Chemical Society (J Am Chem Soc) Vol. 136 Issue 48 Pg. 16712-5 (Dec 03 2014) ISSN: 1520-5126 [Electronic] United States
• PMID: 25407895 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Organometallic Compounds
• Photosensitizing Agents

Topics

• Animals
• Cell Line, Tumor
• Drug Resistance, Neoplasm
• Head and Neck Neoplasms (drug therapy, pathology)
• Humans
• Mice
• Models, Molecular
• Molecular Structure
• Nanostructures (chemistry)
• Neoplasms, Experimental (drug therapy, pathology)
• Organometallic Compounds (chemistry, therapeutic use)
• Photochemotherapy
• Photosensitizing Agents (chemistry, therapeutic use)