Abstract | BACKGROUND: METHODS: A total of sixteen patients with ovarian Sertoli-Leydig cell tumor treated at the Obstetrics and Gynecology Hospital, Shanghai, China, between Jan 2001 and Dec 2011 were reviewed. The clinical data, treatment and prognosis were obtained from medical records. RESULTS: The median age of the patients with ovarian Sertoli-Leydig cell tumor was about 27.5 years old in non-menopausal women, while the median age of menopausal women was about 63 years old. The most common complaint was with hormonal-related symptoms in the form of secondary amenorrhea and infinity, features of virilization, abdominal mass or irregular vaginal bleeding. All of sixteen patients underwent surgical staging and all were found to have stage I disease at the time of diagnosis. Eleven patients with intermediate and two patients with poorly differentiated tumors received adjuvant chemotherapy. There were differences found in operative time, blood loss and postoperative recovery time between laparotomy and laparoscopy. There were no disease-related deaths and all patients were under complete remission at the last follow-up. CONCLUSIONS: Ovarian Sertoli-Leydig cell tumors could happen in any period age of women. However, the tumors typically occur in the single side while still at the early stage, a favorable outcome could be achieved by surgery and adjuvant chemotherapy. Laparoscopy has similar surgical effects as laparotomy, but has a number of advantages.
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Authors | Hai-Yan Zhang, Jia-Er Zhu, Wen Huang, Jin Zhu |
Journal | International journal of clinical and experimental pathology
(Int J Clin Exp Pathol)
Vol. 7
Issue 10
Pg. 6956-64
( 2014)
ISSN: 1936-2625 [Electronic] United States |
PMID | 25400781
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Biopsy
- Blood Loss, Surgical
- Chemotherapy, Adjuvant
- China
- Cytoreduction Surgical Procedures
(adverse effects)
- Female
- Humans
- Laparoscopy
(adverse effects)
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Operative Time
- Ovarian Neoplasms
(pathology, therapy)
- Sertoli-Leydig Cell Tumor
(pathology, therapy)
- Time Factors
- Treatment Outcome
- Tumor Burden
- Young Adult
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