HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Metabolic and glycemic sequelae of sleep disturbances in children and adults.

Abstract
The prevalence of obesity in adults and children has increased greatly in the past three decades, as have metabolic sequelae, such as insulin resistance and type 2 diabetes mellitus (T2DM). Sleep disturbances are increasingly recognized as contributors to this widespread epidemic in adults, and data are emerging in children as well. The categories of sleep disturbances that contribute to obesity and its glycemic co-morbidities include the following: (1) alterations of sleep duration, chronic sleep restriction and excessive sleep; (2) alterations in sleep architecture; (3) sleep fragmentation; (4) circadian rhythm disorders and disruption (i.e., shift work); and (5) obstructive sleep apnea. This article reviews current evidence supporting the contributions that these sleep disorders play in the development of obesity, insulin resistance, and T2DM as well as possibly influences on glycemic control in type 1 diabetes, with a special focus on data in pediatric populations.
AuthorsDorit Koren, Katie L O'Sullivan, Babak Mokhlesi
JournalCurrent diabetes reports (Curr Diab Rep) Vol. 15 Issue 1 Pg. 562 (Jan 2015) ISSN: 1539-0829 [Electronic] United States
PMID25398202 (Publication Type: Journal Article, Review)
Chemical References
  • Blood Glucose
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
Topics
  • Adolescent
  • Blood Glucose (metabolism)
  • Child
  • Circadian Rhythm
  • Glycated Hemoglobin (metabolism)
  • Humans
  • Insulin Resistance
  • Metabolic Syndrome (etiology, metabolism, physiopathology)
  • Pediatric Obesity (etiology, metabolism, physiopathology)
  • Prevalence
  • Sleep Apnea, Obstructive (complications, metabolism, physiopathology)
  • Sleep Deprivation (complications, metabolism, physiopathology)
  • Sleep Wake Disorders (complications, metabolism, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: